Intraarticular Injections of Platelet-rich Plasma in Pain's Treatment of the Osteoarthritic Knee

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Platelet-rich plasma (PRP), due to its high content of cytokines, bioactive proteins and platelet growth factors, may contribute to diminish the pain of arthritic knee. It was also recently recognized a regenerative cell potential improving the concentration of hyaluronic acid and stabilizing angiogenesis in arthritic knees

This study therefore seeks to assess the analgesic power of PRP in osteoarthritic knees intraarticularly infiltrated, and which patients would benefit most from treatment, eliminating false expectations in the rest.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• Arthritis in the knee rated I, II, or III (Kellgren-Lawrence Grading Scale)

• VAS greater than 5

• Between 40and 80 years of age

Exclusion Criteria:

• Level IV arthritis of the knee

• Either surgery, corticoid infiltration, or viscosupplementation in the knee in the previous three months

• Frontal deformity greater than 10 degrees

• Ipsilateral pathology of the knee or ankle

• Range of motion or flexibility of the knee less than 90 degrees

• Deficit of knee extension greater than 15 degrees

• Anticoagulation treatment, antiplatelet treatment

• Hepatopathy

• Hematological neoplastic pathology

• Active infection

• Fibromyalgia

• Chronic fatigue syndrome