Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

• Status: Completed
• Trial end date: 2019-08-20
• Target enrollment: 0
• Participant gender: All

Summary

Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Saint Alphonsus Regional Medical Center
• Treatments: Ketorolac; Triamcinolone

Criteria

Inclusion Criteria:

• Symptomatic, radiographically proven degenerative joint disease in the hip or knee

Exclusion Criteria:

• recent injection in the hip or knee within the previous 3 months

• history of traumatic osteoarthritis or ligamentous reconstruction

• chronic narcotic use

• history of inflammatory or neuropathic arthropathy

• pregnant and/or nursing women

• allergy or strong reaction to study medications