Intraarticular Platelet-rich Plasma Injections Versus Corticosteroid Injections in Primary Knee Osteoarthritis

• Status: Withdrawn
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Aim: To study and compare the clinical effects of platelet-rich plasma (PRP) injections and intra-articular (IA) corticosteroid injections in patients with primary osteoarthritis (OA) of the knee. This study aims to demonstrate this by using the Oxford Knee Score and Western Ontario and McMaster Universities Arthritis Index (WOMAC) to illustrate quantifiable difference between the two treatment modalities. Patient satisfaction will be compared by utilizing the Short-Form Survey-12 (SF-12) Score. Our null hypothesis states that intra-articular PRP injections is more beneficial in the long-term treatment of primary OA of the knee.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: King Hamad University Hospital, Bahrain
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Clinical and radiological diagnosis of Primary Osteoarthritis of Knee joint

• Grade 1, 2, or 3 as per Kellgren and Lawrence radiological grading system.

• Symptomatic at presentation as per Visual Analogue pain scale

• Above 18 years of age

• Consenting to participate

Exclusion Criteria:

• Deformities

• Malalignments

• Rheumatoid lesions

• Gouty lesions

• BMI more than 35

• Use of steroids in the recent 6 weeks

• Pregnant

• Breast feeding

• Active malignancy

• Active infections

• Hemoglobin less than 11

• Platelet less than 150,000/mm3 and

• Bleeding disorders/blood dyscrasias or hemoglobinopathies

• Any contraindications to treatments

• Uncontrolled diabetes.