Intracranial Collaterals in Acute Stroke and Clinical Outcome

• Status: Completed
• Trial end date: 2021-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Assessment of the evolution of intracranial collaterals and its relationship with functional outcomes in acute ischemic stroke (AIS) patients treated with IV tissue plasminogen activator (tPA).

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Tissue Plasminogen Activator

Criteria

IInclusion Criteria:

• Patient presenting to the emergency department with symptoms consistent with ischemic stroke.

• Age > 18 yrs.

• Evidence of a visible and symptomatic intracranial occlusion on baseline CT-angiography (intracranial ICA, M1 MCA segment +/- intracranial ICA, proximal M2 MCA).

• Treatment with IV tPA.

Exclusion Criteria:

• Intracranial hemorrhage (ICH) identified on baseline CT.

• Previous moderate to large stroke in the ipsilesional hemisphere.

• Modified Rankin Scale > 2 at baseline.

• Unable to have CT-angio performed due to recent estimated creatinine clearance eCCr<60 ml/min, contrast allergy or other reasons.

• Any terminal illness (patient not expected to survive > 1 year).