Intralumenal Effects on Cholesterol Absorption/Synthesis
Status:
Completed
Trial end date:
0000-00-00
Target enrollment:
Participant gender:
Summary
The overall goal of this study is to better understand how cholesterol is absorbed and
utilized in the body(metabolism) and how serum cholesterol affects the development of
hardening of the arteries (atherosclerosis). The purpose of aim 1 is to assess the role of
the amount of different bile acids in the intestine and how they affect the absorption,
synthesis and digestion of cholesterol. The effect that these bile acids have on how fast
the gall bladder empties and the release of a hormone in the blood after a meal will also be
studied. The purpose of aim 2 is to assess the role of phospholipid (a fat containing the
element phosphorus) in the intestine and how it affects the absorption, synthesis and
digestion of cholesterol in normal people and in people with a genetic condition (mdr3
deficiency)that affects phospholipid and bile acid metabolism. The purpose of aim 3 is to
assess the role of a material that acts like a detergent called Pluronic F-68 which is known
to block the absorption of cholesterol. The purpose of aim 4 is to determine if the
cholesterol from food and the cholesterol made by the body are digested and absorbed
differently.
Phase:
N/A
Details
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)