Intralymphatic Immunotherapy Enhanced by Vitamin-D, a Randomized Placebo-controlled Trial and Comparison With SLIT
Status:
Recruiting
Trial end date:
2031-12-28
Target enrollment:
Participant gender:
Summary
A national, multicenter, randmised double blind study with parallell arms. 360 patients with
grass induced allergic rhinitis will be open randomised 1:2 to 3 years Grazax sublingual
immunotherapy or 3 intralymphatic injections with ALK Alutard Timothy. In a second step, the
ILIT group will be double blind randomised 1:1 to an intramuscular injection of Vitamin D
Vicotrat or placebo, 4 week before the start of the intralymphatic treatment. The primary
outcome measure is daily combined symptoms and medication scores during grass pollen season.