Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis

• Status: Completed
• Trial end date: 2019-08-02
• Target enrollment: 0
• Participant gender: All

Summary

The proposed study seeks to investigate the effect of intranasal capsaicin treatment in patient with Non-allergic irritant rhinitis (NAIR), as well as evaluate optical rhinometry (ORM) as a means to quantify symptomatic improvement in NAIR patients during and after treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Collaborator: American Academy of Otolaryngic Allergy
• Treatments: Capsaicin; Ethanol

Criteria

Inclusion criteria:

• Non-allergic irritant rhinitis (NAIR) patients as defined by history (symptoms of nasal congestion, rhinorrhea, nasal itching or sneezing upon exposure to nasal irritants)

• Patients with positive optical rhinometer (ORM) response with intranasal challenge with 0.5 millimolar (mM) capsaicin as described by Lambert et al 2012

• Confirmed negative skin prick test to common allergens (which rules out allergic rhinitis)

Exclusion Criteria:

• History of sinonasal surgery

• Chronic rhinosinusitis

• Inflammatory or granulomatous diseases

• Asthma

• Allergic rhinitis

• Immunocompromised state

• Radiation to the head and neck

• Intranasal steroid use >4 wks

• Intranasal or systemic antihistamine x 3 days

• Intranasal or systemic decongestants x 3 days