Intranasal Cocaine and Temperature Regulation During Exercise

• Status: Not yet recruiting
• Trial end date: 2025-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Assess the effects of intranasal cocaine on temperature regulation and whole-body sweat rate during exercise in warm environmental conditions.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Cocaine; Lidocaine

Criteria

Inclusion Criteria:

• 18 to 50 years of age

• Healthy

• Body mass index less than 31 kg/m^2

• Speak English

• Systolic blood pressure <140 mmHg

• Diastolic blood pressure <90 mmHg

Exclusion Criteria:

• Subjects not in the defined age range

• Participants who have cardiac, respiratory, neurological, and/or metabolic illnesses

• Any known history of renal or hepatic insufficiency/disease

• Pregnancy or breast feeding

• Body mass less than 60 kilograms

• Current smokers, as well as individuals who regularly smoked within the past 3 years

• Individuals with a history of drug abuse within the past 5 years

• Individuals who have an unexplained positive urine drug screen (e.g., some agents cause false-positive results and when agent abstained the drug screen is negative, one example could be an over the counter supplement)

• Currently taking pain modifying medications