Intranasal Dexmedetomidine Premedication in Children
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
BACKGROUND INFORMATION AND RATIONALE
Pediatric patients scheduled for dental procedures under general anesthesia can have
significant anxiety before the procedure. They are commonly pre medicated to minimize
distress and to facilitate a smooth induction of anesthesia. Oral Midazolam at 0.5mg/kg dose
is more widely used for this purpose . However the commonly used maximum dose is up to 15mg.
It also has many limitations such as paradoxical reaction, increased incidence of emergence
delirium and negative postoperative behavior changes . Intranasal dexmedetomidine has been
used an effective and safe alternative premedication to oral midazolam in children. At a dose
of 2micrograms/kg, intranasal dexmedetomidine as premedication resulted in excellent sedation
in children aged 5-8yrs with no adverse hemodynamic effects. It has other advantages such as
providing analgesia and facilitating smooth emergence from anesthesia.
The goal of this study is to find out if intranasal dexmedetomidine is a superior alternative
as premedication to oral midazolam in children weighing more than 20kg undergoing general
anesthesia for dental rehabilitation.