Intranasal Dexmedetomidine Premedication

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Most patients with preoperative varying degrees of stress, anxiety, which makes the stress response in patients and affect the normal conduct of anesthesia and surgery.The sympathetic system hyperexcitability prone to cause adverse cardiovascular events and affect postoperative recovery. However, phenobarbital, as the traditional premedication, has less sedative, weak anxiolytic and other shortcomings. Midazolam accompanied by inhibition of respiration,excessive sedation, easily induced delirium,prolonged recovery time and so on. Dexmedetomidine is a highly selective α2-adrenergic receptor agonist, it has sedative, anxiolytic, no inhibition of respiration, and also colorless, odorless, non-mucosal stimulation, nasal drip ease of administration, patient acceptance, comfortable. Therefore, dexmedetomidine as premedication has certain advantages. The purpose of this research is to study sedative effect, safety and the impact of anesthesia recovery period of intranasal dexmedetomidine premedication for suspension laryngoscopy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangzhou First Municipal People’s Hospital; Guangzhou First People's Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Surgery:The laryngoscope vocal polyp excision

• Aged 18 to 60 years old

• Body mass index (BMI) < 30 kg/m2

• American society of Anesthesiologist (ASA) I -II

Exclusion Criteria:

• The investigator refused to participate

• Known allergy or hypersensitive reaction to dexmedetomidine or anesthetic

• With previous history of heart disease

• Pregnant women; no reliable contraceptive measures in postmenopausal women

• Preoperative heart rate less than 45bpm; Ⅱ or Ⅲ degree atrioventricular block; ischemic heart disease

• Taking antihypertensive drugs such as methyldopa, clonidine and other α2 receptor agonist

• Asthma

• Sleep apnea syndrome

• Liver and kidney dysfunction

• Known to suffer from mental illness

• Long-term use of sedatives and analgesics in patients