Abstract Background: Given the inadequate control of pain in patients with injury that refer
to the emergency departments, the rapid onset of action of intranasal administration in pain
management, and the avoidance of administering opioid medications, the present study aimed at
evaluating the effect of intranasal ketamine versus intranasal fentanyl on pain management in
isolated traumatic patients Materials and Methods: The current study was performed on 125
patients that were divided into the following three groups: control group (n = 41), 1 mg/kg
intranasal ketamine group (n = 40), and 1μg/kg intranasal fentanyl group (n = 44). Then pain
scores, HR, RR, BP, and SaO2 were recorded at baseline, 5, 10, 15, 30, and 40 minutes after
the intervention.