Overview

Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting.

Status:
Not yet recruiting

Trial end date:
2022-04-01

Target enrollment:
0

Participant gender:
All

Summary

Postoperative nausea and vomiting (PONV) are common and continue to be persistent problems following general anesthesia. Intranasal lidocaine has been used for the treatment of migraine. The theoretical basis for this effect of intranasal lidocaine on migraine relief is reported to be due to its action on the sodium receptors within the sphenopalatine ganglion. Although there is no reported association between PONV and migraines, injecting lidocaine within the sphenopalatine ganglion has proven to be effective in reducing PONV in endoscopic sinus surgery. The purpose of this study is to investigate the efficacy of intranasal 2% lidocaine in preventing PONV.

Phase:

Phase 4

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Milton S. Hershey Medical Center

Treatments:

Lidocaine

Criteria

Inclusion Criteria:

1. Adults ≥18 years of age

2. ASA Physical status I-III

3. Ability to provide informed consent

4. Pre-surgical COVID-19 negative test

5. Elective, non-cardiac surgery under general anesthesia including breast surgery,
gynecologic surgery, and minimally invasive abdominal surgery

Exclusion Criteria:

1. Local anesthetic allergy

2. Liver diseases

3. Pregnancy

4. Current tobacco use

5. Pre-existing disorders of the gastrointestinal tract

6. Use of anti-emetics within 48 h prior to surgery

7. Chronic use of anti-cholinergic medication or chronic treatment with opioids

8. Any history of nasal pathology (e.g. Nasal ulcer, polyps, and rhinitis)

9. Actual surgical time of <30 min or >180 min

10. Recovery from anesthesia in any location other than PACU

11. History of PONV

12. History of motion sickness

13. Receiving regional blocks for pain management

14. Use of total intravenous anesthesia (TIVA) and/or propofol infusion throughout the
case

15. Aprepitant (Emend) administration

16. Non-English speaking patients