Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery

• Status: Recruiting
• Trial end date: 2026-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investigate the impact of intraoperative blood pressure management and dexamethasone administration on early and long-term outcomes in patients undergoing surgery for lung cancer.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Treatments: Anesthetics; BB 1101; Dexamethasone; Dexamethasone acetate; Glucocorticoids

Criteria

Inclusion Criteria:

• Aged >50 years but <90 years.

• Diagnosed as resectable primary non-small cell lung cancer (stage IA-IIIA) and scheduled for radical surgery with an expected duration of >2 hours.

• Agree to participate in this study and sign the informed consent.

Exclusion Criteria:

• Clinical examinations suggest non-resectable lung cancer or patients scheduled for a biopsy surgery.

• Recurrent or metastatic lung cancer.

• History of cancer or complicated with cancer in other organs.

• Long-term exposure to glucocorticoids or other immunosuppressant(s) due to autoimmune disease or organ transplantation.

• Uncontrolled hypertension (systolic blood pressure >180 mmHg or diastolic blood pressure >110 mmHg); or requirement of vasopressors to maintain blood pressure.

• Persistent atrial fibrillation, or acute cardiovascular events (acute coronary syndrome, stroke, or congestive heart failure) within 3 months.

• Severe hepatic dysfunction (Child-Pugh C) or renal failure (requirement of renal replacement therapy).

• Any other circumstances considered unsuitable for study participation by attending physicians or investigators.