Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

• Status: Completed
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

Comparison of intraoperative infusion of lidocaine and esmolol in the postoperative requirement of opioid for postoperative pain management after laparoscopic cholecystectomy to decrease opioid related side effects and enhance postoperative recovery with multimodal analgesia approach.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: B.P. Koirala Institute of Health Sciences
• Treatments: Acetaminophen; Atropine; Bupivacaine; Ephedrine; Esmolol; Fentanyl; Glycopyrrolate; Ketorolac; Lidocaine; Morphine; Neostigmine; Ondansetron; Propofol; Tramadol; Vecuronium Bromide

Criteria

Inclusion Criteria:

• Adult female patients of ASA physical status I or II, between age of 18 to 60 years undergoing elective laparoscopic cholecystectomy under general anaesthesia.

Exclusion Criteria:

• Refusal to give consent.

• ASA physical status III or more.

• Inability to comprehend pain assessment score or severe mental impairment.

• Difficult intubation.

• Pregnancy.

• Morbid obesity.

• History of epilepsy.

• History of allergy to any drug used in the study.

• History of ongoing use of opioids or beta adrenergic receptor antagonists.

• Baseline heart rate less than 50 beats per minute.

• Presence of pain immediately before surgery.

• Chronic pain other than gall stone disease.

• Gastrointestinal ulceration, bleeding disorder.

• Peritonitis (including previous), perforated gall bladder, severe acute cholecystitis, known to have choledocholithiasis.