Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty

• Status: Withdrawn
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate the efficacy of local infiltration of liposomal bupivacaine versus use of an indwelling femoral peripheral nerve block in controlling early postoperative pain in primary total knee arthroplasty. The investigators hope to demonstrate equivalency of treatment modalities to provide an alternative to the commonly used treatment of femoral nerve blockade.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: United States Naval Medical Center, San Diego
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Age over 18 years old

• Undergoing unilateral primary total knee arthroplasty

Exclusion Criteria:

• Revision total knee arthroplasty

• Bilateral total knee arthroplasty

• Prior allergy or adverse reaction to local anesthetic

• Hepatic dysfunction