Intraoperative Methadone for Postoperative Pain in Patients Undergoing Tonsillectomy

• Status: Not yet recruiting
• Trial end date: 2024-08-01
• Target enrollment: 0
• Participant gender: All

Summary

A randomized controlled trial evaluating the efficacy and safety of single-shot intraoperative methadone for postoperative pain in patients undergoing tonsillectomy. Fentanyl is used as an active comparator

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Treatments: Fentanyl; Methadone

Criteria

Inclusion Criteria:

• All patients (≥15 years) scheduled for elective tonsillectomy

Exclusion Criteria:

• American Society of Anaesthesiologists (ASA) physical status IV or V

• Allergy to study drugs

• Daily use of opioids 7 days prior to surgery

• Inability to provide informed consent

• Severe respiratory insufficiency

• Heart failure

• Acute alcohol intoxication/delirium tremens

• Increased intracranial pressure

• Acute liver disease

• Liver insufficiency

• Kidney insufficiency

• Treatment with rifampicin

• Treatment with any drug prolonging the QT-interval

• Pregnancy (every female not using contraceptives will be screened with urine human choriogonadotropin)

• Breastfeeding