Intraoperative Methadone in Children Undergoing Surgery

• Status: Recruiting
• Trial end date: 2022-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in 96 children undergoing open urological surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Treatments: Methadone

Criteria

Inclusion Criteria:

Children scheduled for open urological surgery at the Outpatient Clinic at Aarhus University Hospital.

Exclusion Criteria:

• Age =/> 5 years at the date of operation

• Born preterm (Before gestational age of 37 weeks)

• Congenital heart disease

• Previous scrotal surgery

• Laparoscopic operation

• American Society of Anaesthesiologists (ASA) physical status lll, IV or V

• Allergy to study drugs

• Preoperative daily use of opioids

• Parents with inability to provide informed consent

• Severe respiratory insufficiency

• Acute abdominal pain

• Severe kidney insufficiency

• Treatment with rifampicin