Intraoperative Opioids and Postoperative Recovery After Hepatobiliary or Foregut Surgery

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of this randomized, double-blind study is to examine the effect of a single intraoperative dose of methadone on analgesic requirements during the first three days after hepatobiliary or foregut surgery. These patients will be compared to subjects receiving a standard dose of the "traditional" intraoperative opioid (hydromorphone). Secondary outcome measures to be assessed will include postoperative pain scores and standard recovery variables such as hospital length of stay.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: NorthShore University HealthSystem; NorthShore University HealthSystem Research Institute
• Treatments: Anesthetics; Hydromorphone; Methadone

Criteria

Inclusion Criteria:

• All patients presenting for elective hepatobiliary or foregut surgery will be eligible for enrollment

Exclusion Criteria:

• Exclusion criteria include:

1. Preoperative renal failure (defined as a serum creatinine > 2.0 mg/dL.)

2. Morbid obesity

3. American Society of Anesthesiologists Physical Status IV or V

4. Age > 80 years

5. Pulmonary disease necessitating home oxygen therapy

6. Allergy to methadone or hydromorphone

7. Preoperative recent history of opioid or alcohol abuse