Intraoperative Sedatives and Postoperative Deilirium
Status:
Recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
Delirium occurs commonly in elderly patients. Its incidence after orthopedic surgery has been
reported to be 5-61%. Delirium is classified into three sub-types: Hypoactive, hyperactive,
and mixed. Although hyperactive delirium is not as common as hypoactive delirium, the
abnormal behavior pattern of hyperactive delirium, such as agitation, confusion, or
aggressiveness, is considered to be harmful to patients and medical personnel. Thus, it is
important to promptly manage such behaviors associated with hyperactive delirium.
Intraoperative sedation plays an important role in relieving anxiety or stress response of
patients. Propofol-a common sedative agent-was reported to cause delirium more frequently,
compared with dexmedetomidine, in post-cardiac surgery patients or mechanically-ventilated
patients in the intensive care unit (ICU). In addition to the benefits of reducing opioid
consumption and postoperative nausea/vomiting, dexmedetomidine is most often used for ICU
sedation or procedural sedation. However, there has not been any prospective randomized study
investigating how intraoperative dexmedetomidine sedation during regional anesthesia affects
postoperative consciousness, perception, memory, behavior, emotion, and so on. In this study,
based on the hypothesis that intraoperative dexmedetomidine sedation may reduce the incidence
of abnormal psycho-motor behavior compared with propofol sedation, investigators
prospectively will investigate the incidence of postoperative delirium in elderly patients
who undergo orthopedic surgery with regional anesthesia.