Overview
Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients
Status:
Recruiting
Recruiting
Trial end date:
2020-12-30
2020-12-30
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study aim to determine whether a small-dose esketamine infusion can be used for pain control in severe burn patients, and thereby reduce the total intra-operative opioid requirement. Secondary objectives are to determine whether this low-dose esketamine infusion will increase the stability of circulation.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang UniversityTreatments:
Esketamine
Criteria
Inclusion Criteria:- All intubated adult burn patients( age>18 ), presenting to the operating room;
- Burn area> 30%.
Exclusion Criteria:
- Allergy to Esketamine or benzodiazepines
- Esketamine or ketamine use in the preceding 24 hours
- Increased intracranial pressure
- Increased intraocular pressure
- Porphyria
- Thyroid disorders
- Seizures
- Acute myocardial ischemia
- Children (patients under age 18), prisoners, pregnant or breastfeeding women, patients
with psychosis, patients with developmental delay, and any condition which, in the
opinion of the investigator, would prevent full participation in this study or would
interfere with the evaluation of the trial endpoints.