Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the use of IV acetaminophen (Ofirmev) as a and safe and efficacious agent in reducing post-operative pain; we hypothesize that its use will reduce post-operative pain when compared to a control group using the visual analogue score (VAS) analog pain scoring system.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Collaborator: Mallinckrodt
• Treatments: Acetaminophen; Analgesics

Criteria

Inclusion criteria:

1. Patients undergoing surgical management for CRS (with or without polyps)

2. Operating time must be at least 2 hours in duration.

3. Number of sinuses involved must be 3 or greater

Exclusion criteria:

1. History of hypersensitivity to acetaminophen

2. End stage renal disease

3. End stage liver disease

4. History of chronic pain, or use of opioid medication in the previous two weeks

5. Severe depression or anxiety

6. Use of gabapentin or any other pain modulator

7. History of acute sinusitis or mucocele

8. History of seizures

9. Known or suspected history of alcohol or drug abuse

10. Known or suspected history of morphine intolerance