The research team wants to investigate if an intraosseous injection (directly into the bone
marrow) of morphine during primary total knee replacement helps with post-operative pain
following primary total knee replacement surgery. For this study patients will either be
randomized into one of two groups: Group 1: Receives an intraosseous injection of morphine
(mixed with standard antibiotics) during their primary total knee replacement or Group 2:
Serves as the control group and only receives an intraosseous injection of antibioitics
during their total knee replacement. The research team will have patients fill out a symptom
journal for two weeks following their surgery to measure pain levels and pain medication
consumed throughout the day as well as nausea and other symptoms. Additionally, the research
team will take blood samples both intraoperatively and post-operatively (10 hours post-op) to
measure the level of inflammatory markers as well as morphine.
Phase:
Phase 4
Details
Lead Sponsor:
The Methodist Hospital Research Institute The Methodist Hospital System