Intraosseous With Intra-articular Injection of Platelet Rich Plasma in Treatment of Knee Osteoarthritis

• Status: Completed
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP), intra-articular injection of PRP and a single application of hyaluronic acid (HA).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cangzhou Central Hospital
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• Unilateral symptomatic knee with pain for at least 1 month or swelling.

• Radiographic findings of knee degeneration (Kellgren-Lawrence score of II - III).

• Age 40-73 years.

• Body mass index (BMI) 18-32.5).

• Knee stability without a severe trauma history.

Exclusion Criteria:

• Bilateral knee osteoarthritis indicative of treatment for both knees.

• Kellgren-Lawrence score greater than III.

• BMI >32.

• Age >73 years.

• Systemic autoimmune rheumatic diseases and blood disorders.

• Active immunosuppressive or anticoagulant therapy.

• Intra-articular injection to the knee within the previous 1 year or previous joint infection.

• use of corticosteroids for 3 weeks before the procedure.

• use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the 3 weeks before treatment.