Overview

Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis

Status:
Completed

Trial end date:
2018-07-17

Target enrollment:

Participant gender:

Summary

The objective of this trial is to evaluate if intraoperative intraperitoneal administration of fosfomycin, metronidazole and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) followed by oral antibiotic for three days is as effective as the current intravenous antibiotic treatment given during and three days after appendectomy for perforated appendicitis. The primary outcome is the total length of hospital stay, defined as the number of hours in hospital after end of operation and until 30-day follow-up.

Phase:

Phase 2

Details

Lead Sponsor:

Herlev Hospital

Collaborator:

Bispebjerg Hospital

Treatments:

Anti-Bacterial Agents
Antibiotics, Antitubercular
Fosfomycin
Metronidazole
Molgramostim