Intraperitoneal Dexmedetomidine Versus Ketamine With Bupivacaine For Postoperative Analgesia

• Status: Recruiting
• Trial end date: 2021-10-20
• Target enrollment: 0
• Participant gender: All

Summary

Post-laparoscopic sleeve pain management is essential for early mobilization of the patient and so on decrease post-operative complication. The use of opioids is associated with adverse effects such as nausea, pruritus, sedation, and occasionally respiratory depression.

Previous studies stated that intraperitoneal instillation of bupivacaine alone has been used to reduce acute postoperative abdominal and shoulder pain allow early mobilization and decrease postoperative opioid requirements and its complications.

In this study the investigators will compare between intraperitoneal instillation of dexmedetomidine with bupivacaine versus ketamine with bupivacaine in patients undergoing laparoscopic sleeve gastrectomy under general anesthesia regarding to postoperative pain relief to reduce morbidity and mortality.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zagazig University
• Treatments: Dexmedetomidine; Ketamine

Criteria

Inclusion Criteria:

• Patient acceptance.

• Age 21-60 years old.

• Sex both male and female.

• BMI ≥40 kg/m2

• ASA II and ASA III.

• Scheduled for elective laparoscopic sleeve gastrectomy under general anesthesia.

Exclusion Criteria:

• Patients with known history of allergy to study drugs.

• Patients with uncontrolled diabetes mellitus.

• Psychological and mental disorders.

• Severe hypertensive, cardiac, hepatic and renal patients.

• Patients on opioid or sedative use.