Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage

• Status: Completed
• Trial end date: 2018-08-24
• Target enrollment: 0
• Participant gender: Female

Summary

This study aims to compare the effect of chloroprocaine vs. bupivacaine on duration of motor block and duration until meeting discharge criteria in patients undergoing cervical cerclage. The hypothesis is that chloroprocaine will result in faster resolution of motor block.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tufts Medical Center
• Treatments: Bupivacaine; Chloroprocaine; Procaine

Criteria

Inclusion Criteria:

• ASA classification II or III females

• Age: 18-45 years old

• BMI ≤ 50 kg/m2

• Singleton pregnancy

• Simple prophylactic cervical cerclage

• Planning neuraxial anesthesia

Exclusion Criteria:

• Abdominal and complex cervical cerclage (e.g. bulging bag)

• Contraindication to neuraxial anesthesia

• Known hypersensitivity to chloroprocaine (a.k.a. Ester allergy), paraaminobenzoic acid (PABA) or bupivacaine (a.k.a. Amide allergy)

• Pseudocholinesterase deficiency

• Concomitant use with ergot-type oxytocic drugs