Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

VATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg/kg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chicago
• Treatments: Morphine

Criteria

Inclusion Criteria:

• Age 18-80 years old

• Undergoing elective video-assisted thoracoscopic surgery for anatomical lung resection

• General anesthesia with anticipated intraoperative extubation.

Exclusion Criteria:

• American Society of Anesthesiologists (ASA) classification of 4 or 5

• Anticipated postoperative intubation

• Significant liver disease

• Preoperative use of intravenous inotropes and/or vasopressor support

• Preoperative mechanical ventilation

• Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)

• Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)

• Morphine allergy

• Opioid or alcohol abuse

• Chronic pain

• Renal failure

• Inability to comprehend English language

• Bleeding disorder

• Abnormal preoperative coagulation

• Infection

• Patient refusal