Intratumoral Poly-ICLC Plus Low Dose Local Radiation in Low Grade Recurrent B and T Cell Lymphoma
Status:
Terminated
Trial end date:
2011-04-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to evaluate the safety of intratumoral
Polyinosinicpolycytidylic acid stabilized with polylysine and carboxymethylcellulose
(poly-ICLC)(Hiltonol®) in addition to low-dose local radiotherapy for adult patients with low
grade lymphomas, including follicular lymphoma, marginal zone lymphoma, small lymphocytic
lymphoma, chronic lymphocytic leukemia, and cutaneous T-cell lymphoma. The secondary
endpoints are response rate, immune responses, and durability of responses as well as
generation of antiinflammatory response at sites of tumor involvement.