Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSI
Status:
Completed
Trial end date:
2018-07-30
Target enrollment:
Participant gender:
Summary
Despite recent advances in clinical and laboratory techniques of Assisted Reproductive
Technology (ART), the pregnancy rate remains around 30% per cycle. It has been estimated that
50% to 75% of lost pregnancies are due to failure of implantation.
The process of implantation is a locally controlled paracrine/juxtacrine-mediated phenomenon.
Successful implantation depends on the synchronized "cross-talk" between a functional
blastocyst and a "receptive" endometrium. This process leads to apposition, attachment and
invasion of embryos and subsequent normal placentation. So the objective of this study is
investigate the impact of intrauterine injection of human chorionic gonadotropin (hCG) at the
day of ovum pick-up on implantation and pregnancy rates in patients with recurrent
implantation failure.