Intravaginal Isosorbide Mononitrate in Addition to Misoprostol Versus Misoprostol Only for Induction of Labor

• Status: Unknown status
• Trial end date: 2018-11-30
• Target enrollment: 0
• Participant gender: Female

Summary

Evaluation of safety & efficacy of nitric oxide donors such as intravaginal isosorbide mononitrate in addition to misoprostol Versus misoprostol only for the whole process of induction of labor.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dina Yahia Mansour
• Treatments: Isosorbide; Isosorbide Dinitrate; Isosorbide-5-mononitrate; Misoprostol

Criteria

Inclusion Criteria:

• Primigravida.

• From 20 to 30 years old.

• Singleton term (between 40 to 42 weeks of gestation).

• Good general condition with straightforward enthusiasm for the trial.

Exclusion Criteria:

• IUGR.

• Rupture of membranes.

• Favorable cervix (Bishop score : '8' or more)

• Cephalopelvic disproportion,fetal malpresentation.

• Antepartum hemorrhage, any abnormal placentation such as placenta previa, accreta, increta and percreta

• Uterine fibroid.

• Previous uterine major surgery such as : myomectomy, uterine repair caused by trauma and metroplasty for Mullerian anomalies.

• Any medical disorder such as : gestational diabetes, diabetes mellitus, hypertension, preeclampsia, renal & hepatic dysfunction, coagulation disorders.