Intravenous Acetaminophen/Ibuprofen Fixed-dose Combination on Postoperative Opioid Consumption

• Status: Not yet recruiting
• Trial end date: 2024-05-30
• Target enrollment: 0
• Participant gender: All

Summary

This prospective, randomized, double-blinded study is designed to evaluate the postoperative analgesic effect of the intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing video-assisted thoracic surgery (VATS). We hypothesize that the intravenous acetaminophen/ibuprofen fixed-dose combination can significantly reduce postoperative opioid consumption and pain severity in patients with VATS.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Collaborator: Kyongbo Pharmaceutical
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• Patients scheduled to undergo elective unilateral VATS segmentectomy or lobectomy under general anesthesia

• American Society of Anesthesiologists (ASA)physical classification I-II

• Consent to IV-patient controlled analgesia use

• Willingness and ability to sign an informed consent document

Exclusion Criteria:

• Do not understand our study

• Allergies to anesthetic or analgesic medications

• Continuous local anesthetics infiltration for postoperative pain control

• Patients who receive mechanical ventilation more than 2 hours after surgery

• Pregnancy/Breastfeeder

• Medical or psychological disease that can affect thetreatment response