Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department

• Status: Recruiting
• Trial end date: 2022-06-03
• Target enrollment: 0
• Participant gender: All

Summary

In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine. However, the data are sparse to support this strategy. Thus, the purpose of our research is to test non-inferiority of IV morphine alone versus IV acetaminophen and morphine in a multicenter, randomized, controlled double blind trial in ED patients with moderate to severe acute pain.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nantes University Hospital
• Treatments: Acetaminophen; Morphine

Criteria

Inclusion Criteria:

• 18 Years and older

• Moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5.

• Conscious patient

• Clinical stability at the physician's discretion

• Patient able to talk and give a verbal assessment of his/her pain with the numerical verbal scale

• Out of guardianship and/or tutorship

• Affiliated to the social security plan.

Exclusion Criteria:

• Pregnancy and Breast-feeding

• Patient Unable to give numeric rating scale scores

• Patient with a weight strictly less than 50kg.

• acute pulmonary edema, acute respiratory failure

• Acute coronary syndrome or unbalanced ischemic heart disease in progress.

• Acute alcoholic intoxication.

• Patient who received morphine, or acetaminophen, or analgesic, or anti-inflammatory, for the current acute pain episode, within 8 hours prior to arrival at the emergencies

• No possibility of having venous access

• History of chronic pain during treatment.

• Allergy, intolerance or know contraindication to paracetamol or morphine or to an excipient.

• Renal or hepatic insufficiency.

• Association with buprenorphine, nalbuphine and pentazocine.

• Patient unable or unable to give written consent.