Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis

• Status: Unknown status
• Trial end date: 2020-11-01
• Target enrollment: 0
• Participant gender: All

Summary

To investigate an economical and effective way to reduce the level of serum triglyceride in patients with hypertriglyceridemia-induced acute pancreatitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College Hospital
• Collaborators: Cangzhou Center Hospital; First Affiliated Hospital of Kunming Medical College; First Affiliated Hospital, Sun Yat-Sen University; First Hospitals affiliated to the China PLA General Hospital; Fujian Provincial Hospital Emergency Center; General Hospital of Ningxia Medical University; Guangdong Provincial Hospital of Traditional Chinese Medicine; Jinhua Central Hospital; Nanjing General Hospital; Shenzhen Baoan District People 's Hospital; The First Affiliated Hospital with Nanjing Medical University; The First Hospital of Hebei Medical College; The General Hospital of Shenyang Military; Tianjin Medical University General Hospital; Wuxi Third People 's Hospital
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

1. Adult aged 18 to 80 years old;

2. abdominal pain consistent with AP;

3. serum amylase and / or lipase activity is at least 3 times higher than the normal upper limit;

4. abdominal imaging consistent with AP imaging changes.

5. severe hyperlipidemia "fasting serum TG> 1,000 mg/dL (11.2mmol/L)";

6. except for other AP causes, such as cholelithiasis, alcohol, drugs and so on.

Exclusion Criteria:

1. other etiologies other than hyperlipidemia leading to AP;

2. fasting serum TG less than 1,000 mg / dL (11.2mmol / L);

3. acute lipid-induced pancreatitis at the same time combined with other etiologies of acute pancreatitis.

4. the existence of plasma replacement contraindications: serious allergies to plasma, human serum albumin, heparin and others; the existence of mental disorders; unstable heart or cerebral infarction; intracranial hemorrhage or severe cerebral edema associated with hernia.

5. without informed consent, the patient refused to plasma replacement, and other circumstances may bring significant bias.