Intravenous Anesthesia Versus Anesthesia With Volatile Agents in Elective Craniotomy for Tumors

• Status: Withdrawn
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

If the anesthetic regimen can influence the serum level of inflammatory cytokines and if the levels of cytokines are related to the incidence of post operative complications, these complications may be a function of the anesthetic method. In an effort to find the best anesthetic regimen for patients undergoing craniotomy for intracranial tumors, the researchers will compare the effect of volatile anesthetic with that of total intravenous anesthesia (TIVA) on cytokine levels. The researchers will also compare the composite incidence of some common major post-operative complications after craniotomy for intracranial malignancy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• Patients undergoing general anesthesia for elective surgical excision of a primary brain tumor

• Age: Older than 18

• New and recurrent cases will be included

Exclusion Criteria:

• Patient refusal

• Emergency craniotomy

• Craniotomy after head injuries or intracranial bleeding

• Patients with active inflammatory processes such as infection or immunologic illnesses known to increase baseline immunologic markers

• Preoperative diagnosis of DVT by lower extremity ultrasound or symptoms

• Preoperative pulmonary infiltrative disease (pulmonary fibrosis, sarcoid, etc.)

• Pregnancy