This multi-centric study analyses the effect of intravenous branched-chain amino acids (BCAA)
on overt HE in patients with ACLF. The investigators aim to study the efficacy of combining
intravenous BCAA with lactulose versus lactulose alone, ammonia measures, endotoxin,
metabolomics, and cerebral edema in the medical management of overt HE in patients with ACLF.
The study will also access the impact on overall survival and improvement in the grade of HE.
Phase:
Phase 1
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research
Collaborators:
All India Institute of Medical Sciences, Bhubaneswar Amrita Institute of Medical Sciences & Research Center Asian Institute of Gastroenterology, India Kalinga Institute of Medical Sciences, Bhubaneswar