Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study

• Status: Completed
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Critically ill infants and children who are mechanically ventilated are often given large doses of opiates and benzodiazepines to provide analgesia-sedation. These drugs significantly cause tolerance and dependence, depresses the drive to breathe, and thus prolongs the need for mechanical ventilation and the associated complications. We propose IV CLON could be used as effectively as DEX.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gauda, Estelle B., M.D.; Johns Hopkins University
• Treatments: Clonidine

Criteria

Inclusion Criteria:

• Infants and children age: 0-12 months

• Intubated and mechanically ventilated in the JHH PICU

• Meet criteria for starting dexmedetomidine (per PICU protocol)

Exclusion Criteria:

• Postoperative from complex congenital heart disease

• Asphyxia

• Traumatic Brain Injury

• Major Chromosomal anomaly (Trisomy 13, 18)

• Any infant or child who is receiving ECMO therapy

• If death is considered imminent