Intravenous Dexamethasone on Supraclavicular Brachial Plexus Block for Shoulder Arthroscopy

• Status: Completed
• Trial end date: 2017-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Previous studies have confirmed that IV dexamethasone prolongs brachial plexus blocks. However, these studies only used fixed doses of IV dexamethasone at relatively high doses, which could potentially lead to increased glucose levels, delayed wound healing, and unintended side effects. There remains a paucity of research on the effective dose range of IV dexamethasone for the prolongation of supraclavicular blocks. The optimal dosage of IV dexamethasone for prolongation of analgesia vs. motor block prolongation from supraclavicular blocks in shoulder surgery has yet to be delineated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital for Special Surgery, New York
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Patients undergoing shoulder arthroscopy under regional anesthesia

Exclusion Criteria:

• General anesthesia

• Contraindication to regional anesthesia

• Pre-existing neuropathy in the surgical limb

• Diabetes Mellitus

• History of postoperative nausea and vomiting &/ or motion sickness

• Procedures involving biceps tenotomy

• Peri-articular cocktail injections given intraoperatively to augment pain relief

• Chronic pain (daily opioid and/or gabapentinoid use for 6 weeks)

• Open surgical procedures

• Corticosteroid injection within 1 month

• Patients on systemic oral or IV steroid therapy within 6 months