Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with acute migraine attack make up the majority of patients consulting the emergency services due to headache. The aim of treatment in the emergency service is to achieve a minimum level of undesirable side effects and to quickly relieve the pain which will not repeat after discharge from the emergency service. Ideal drug treatment contraindication should be at a minimum level and not trigger migraine. Paracetamol and Nonsteroidal anti-inflammatory drugs are often used in the treatment of migraine headache.

Although narcotic analgesics provide effective and rapid analgesia, they have such side effects as hypotension, nausea and vomiting, drowsiness. In recent years, with the production of parenteral forms of non-steroidal anti-inflammatory painkillers, the analgesic efficacy of these drugs has been one of the topics of interest to researchers. Especially intravenous form of paracetamol is new yet compared to other Nonsteroidal anti-inflammatory drugs, and it is a drug with a wide safety margin and less incidence of side effects. The effectiveness of the Intravenous form of paracetamol and whether it can be an alternative to other analgesics is one of the major research topics today, and more study is needed on this subject.

Both drugs are often used in emergency services to treat headache caused by acute migraine attack. Our aim is to compare the effectiveness of intravenous dexketoprofen with paracetamol in the treatment of the headache caused by acute migraine attack.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pamukkale University
• Treatments: Acetaminophen; Dexketoprofen trometamol

Criteria

1. Inclusion Criteria:

a. Patients who are 18 years of age and older, and who agreed to participate in the study will be included in the study.

2. Exclusion Criteria:

1. Patients having received analgesic in the last six hours,

2. pregnant women,

3. women of childbearing potential and not using birth control,

4. those who do not agree to participate in the study,

5. those under age of 18, those who have signs of peritoneal irritation,

6. those who are allergic to drugs used in the study,

7. hemodynamically unstable patients,

8. patients with renal transplant,

9. those who suffer from liver, kidney, cardiac and pulmonary insufficiency and others with systemic diseases,

10. patients with vision problems and those who are illiterate will be excluded from the study.