Intravenous Dexmeditomidine for Prevention of Spinal Anesthesia Induced Shivering.

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

Intraoperative and post operative shivering is a common problem encountered in operating rooms and recovery suites. Shivering under spinal anesthesia has an incidence of 40-60%. Shivering is not only uncomfortable for the patient; additionally it increases minute oxygen consumption, subjecting the patient to a higher risk of cardiovascular complications. A variety of drugs like pethidine, fentanyl, alfentanil, sufentanil, buprenorphine, doxapram, clonidine, and ketanserin, are reported to be effective in suppressing postoperative shivering, yet an ideal drug/ method to be explored. Dexmeditomidine, a sedative and analgesic, may control shivering without significant adverse effects, like nausea and vomitting and respiratory depression.

The study design will be randomized controlled parallel trials with sample size of 80,They will be randomized into two equal groups. One group will receive 10 microgram Inj. Dexmeditomedine while the other will recieve inj. normal saline as placebo. They will be assessed for intra- and postoperative shivering.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rehman Medical Institute - RMI
• Treatments: Dexmedetomidine

Criteria

Inclusion criteria:

• American Society of Anesthesiologists (ASA) physical status I and II ladies

• Singleton pregnancies.

• Undergoing elective Cesarean delivery under spinal anesthesia.

• Systolic blood pressure ≥ 100 mm of Hg after umbilical cord clamping

Exclusion criteria:

• ASA class III or above

• Hyperthyroidism

• Cardiopulmonary or respiratory disease

• A psychological disorder

• An initial body temperature of >37.5 °C or <36.5 °C

• Systolic blood pressure <100 mm of Hg after umbilical cord clamping and/or mean arterial pressure (MAP) < 65 mm of Hg after umbilical cord clamping