Intravenous Erythromycin Before Endoscopy in Patients With Variceal Bleeding: A Randomized, Double-Blind Trial

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Objectives:

Blood in stomach & oesophagus in patients with variceal bleeding often obscures the endoscopic view & makes endoscopic intervention difficult to perform. Erythromycin, a motilin agonist induces gastric emptying. The aim of this study was to assess the effect of Erythromycin on endoscopic visibility and its outcome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: King Abdulaziz Medical City
• Treatments: Anti-Bacterial Agents; Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin lactobionate; Erythromycin stearate

Criteria

Inclusion Criteria:

• Adult patients with liver cirrhosis or stigmata of chronic liver disease presenting with hematemesis and or melena within previous 12 hours with

• Age >18 years

• Informed consent

• Hemodynamically stable patient at the time of endoscopy after resuscitation.

Exclusion Criteria:

• Known allergy to erythromycin

• Prior gastric lavage on admission

• Current use of antiarrhythmic drugs

• Prior gastric surgery

• Previous history of cardiac arrhythmias

• Concomitant use of antihistaminic drugs with possible drug interactions with erythromycin

• Prior use of other prokinetic agents

• Pregnancy or lactation