Intravenous High Dose NAC and Sodium Bicarbonate for the Prevention of Contrast-induced Acute Injury
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Contrast-induced acute kidney injury is a common cause of acquired in-hospital renal
insufficiency and is associated with prolonged hospitalization and unfavorable early and late
outcomes. The investigators sought to compare 4 different strategies (intravenous high-dose
of N-acetylcysteine, sodium bicarbonate, the combination of both, and saline alone) in the
prevention of contrast-induced acute kidney injury in patients undergoing coronary
angiography using high-osmolar contrast media defined by creatinine and cystatin C serum
levels.
Phase:
N/A
Details
Lead Sponsor:
Federal University of São Paulo
Collaborators:
Hospital das Forças Armadas, Brazil InCor Heart Institute