Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Children are at risk of developing an involuntary movement disorder after streptococcal throat infections. Not all children are affected and the severity is individually variable. Affected children have alteration in their behaviour and mood and can become quite compromised in their activities of daily living. The condition is believed to be related to the body having an over efficient immune response to the infection and some of the antibodies made in response to the infection also "attack" centres in the brain controlling movement and mood. Treating these children with immunoglobulins, which "mop up" the antibodies may reverse or improve affected children. This study hopes to clarify this.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Cape Town
• Collaborator: Natal Bioproducts Institute
• Treatments: Antibodies; gamma-Globulins; Haloperidol; Haloperidol decanoate; Immunoglobulins; Immunoglobulins, Intravenous; Penicillin V; Penicillins; Rho(D) Immune Globulin

Criteria

Inclusion Criteria:

• Sydenham chorea moderate to severe (affecting activities of daily living) Raised ASOT titre

Exclusion Criteria:

• Mild Sydenham chorea (not affecting activities of daily living)

• Exclusion of systemic lupus erythematosus

• Exclusion of Wilson's disease

• Exclusion of toxin ingestion