Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Children are at risk of developing an involuntary movement disorder after streptococcal
throat infections. Not all children are affected and the severity is individually variable.
Affected children have alteration in their behaviour and mood and can become quite
compromised in their activities of daily living. The condition is believed to be related to
the body having an over efficient immune response to the infection and some of the antibodies
made in response to the infection also "attack" centres in the brain controlling movement and
mood. Treating these children with immunoglobulins, which "mop up" the antibodies may reverse
or improve affected children. This study hopes to clarify this.