Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients

• Status: Withdrawn
• Trial end date: 2018-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if an intravenous lidocaine infusion (compared to placebo) intraoperatively will decrease time to return of bowel function postoperatively, decrease postoperative pain, diminish postoperative opioid requirement, minimize inflammatory markers and shorten time to discharge after colorectal surgery.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Hospital Medical Center, Cincinnati
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• male or female children 1-15 years of age

• ASA physical status 1-3

• scheduled for colorectal surgery with abdominal incision

• scheduled for complex urology surgical case

Exclusion Criteria:

• ASA physical status > 3

• postoperative intubation planned ahead of surgery

• history of chronic use of opioid

• history of hepatic,renal, or cardiac failure

• history of organ transplant

• BMI > 30

• history of cardiac arrhythmia

• history of long QT syndrome

• history of allergic reaction to lidocaine or similar agents

• history of seizure disorder

• patient without Peripherally Inserted Central Catheter or other central access with contraindication to inhalation induction

• family history or know patient susceptibility to malignant hyperthermia