Intravenous Lidocaine and Postoperative Outcomes After Cardiac Surgery

• Status: Terminated
• Trial end date: 2014-12-15
• Target enrollment: 0
• Participant gender: All

Summary

This study is being done to determine if lidocaine, administered during surgery and for 24 hours after surgery can reduce inflammation, thereby reducing the risk of atrial fibrillation and 30 day mortality after surgery. Participants undergoing cardiac surgery will be randomized to receive either lidocaine or placebo.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Age 18-90 years old

• Scheduled for cardiac surgery requiring cardiopulmonary bypass

• Written informed consent

Exclusion Criteria:

• Off-pump surgical procedures

• Anticipated deep hypothermic circulatory arrest

• Any contraindications to the proposed interventions including lidocaine allergy

• History of preoperative atrial fibrillation

• Baseline Screening revealing preexisting dementia or delirium

• Preoperative liver failure defined as Child-Pugh Score > 6