Intravenous Lidocaine in Open Lung Resection Surgery

• Status: Completed
• Trial end date: 2020-05-15
• Target enrollment: 0
• Participant gender: All

Summary

Management of postoperative pain in 2020 remains a challenge for anesthesiologists in the perioperative period. Lidocaine is an amide local anesthetic, it is one of the oldest adjuvant analgesics and is known to possess analgesic, anti-hyperalgesic and anti-inflammatory properties. Lidocaine is proven to be as effective as epidural analgesia in colorectal surgery.

However, no study has evaluated the effect of a continuous lidocaine infusion for open lung resection in the post-operative period. The present study aims to evaluate the influence of IV lidocaine given during and 24 hours after surgery, on pain scores, opioid consumption, and possible benefits on patient outcome via the opioid-sparing effect in open thoracic surgery

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Saint-Joseph University
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• American society of anesthesiologists (ASA) scores of I, II or III.

• Left or right posterolateral thoracotomy with postoperative monitoring in the intensive care unit (ICU) for at least 24 hours (h).

Exclusion Criteria:

• patient's refusal to participate

• ASA score of IV or higher

• severe hepatic or renal insufficiency

• allergy to lidocaine, morphine or NSAIDs

• cardiac arrhythmias or

• epilepsy,

• delayed extubation for more than 2 h postoperatively

• urgent surgery