Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence

• Status: Unknown status
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Introduction: Although inflating tracheal cuff using lidocaine is effective for cough suppression, it may pressure tracheal cuff too much. Intravenous continuous infusion of lidocaine has emerged recently for most general anesthesia in the context of opioid-sparing anesthesia for cancer, but the 95% effective dose (ED95) for cough suppression during anesthesia emergence is not determined yet. Objective: the objectives of this study are to determine the ED95 of continuous infusion lidocaine for suppressing cough reflex during extubation by sex and age group.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brasilia University Hospital
• Treatments: Anesthetics; Lidocaine

Criteria

Inclusion Criteria:

• Understands study risks and benefits, signs informed consent.

• Not pregnant.

• Not an airway surgery

• No acute or chronic respiratory disease.

• Non smoker

• No chronic cough

Exclusion Criteria:

• Any protocol violation.