Intravenous Metoclopramide for the Treatment of Post Concussive Headache: a Randomized Placebo Controlled Trial
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Concussion is defined as any temporary disturbance in brain function following a blow to the
head. It may not involve a loss of consciousness and usually results in a post concussive
headache (PCH) immediately after the injury. Between 30 and 50 percent of patients with
concussion will develop postconcussive syndrome (PCS) consisting of symptoms such as
headache, and a variety of other debilitating symptoms lasting several weeks to months.
The objective of this study is to determine if metoclopramide, a drug commonly used in the
treatment of migraine headache, will be effective in relieving PCH and in preventing PCS.
Eligible patients will have a history of a concussion resulting in headache within the past
24 hours. Patients will rate their pain on a standard scale before and after being treated
with one or two intravenous doses of either metoclopramide or saltwater placebo. They will be
contacted by telephone 1, 4 and 8 weeks later in order to determine if they have developed
the postconcussive syndrome.