Overview

Intravenous Paracetamol for Postoperative Pain

Status:
Completed
Trial end date:
2017-03-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to define if intravenous paracetamol may improve analgesia and outcome in pediatric surgical patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) postoperatively. Hypothesis: intravenous paracetamol in a dose 60 mg/kg/24 h IV, given in addition to IV ketoprofen (4,5 mg/kg/24h), improves analgesia and physical recovery in children and adolescents following surgery.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Lithuanian University of Health Sciences
Treatments:
Acetaminophen
Anti-Inflammatory Agents, Non-Steroidal
Ketoprofen
Morphine
Pharmaceutical Solutions
Tramadol
Criteria
Inclusion Criteria:

- Patients 1-18 years of age, undergoing general, plastic or orthopedic surgery with
expected median to severe pain postoperatively.

- physical status of the patient corresponding to American Society of Anesthesiologists
(ASA) class 1 or 2

- Signed written informed consent by parents/official caregivers.

Exclusion Criteria:

- Allergy to paracetamol, ketoprofen, tramadol, morphine or any NSAID

- oncologic disease

- central nervous system disease

- renal dysfunction

- hepatic dysfunction

- bronchial asthma

- ulcer(s) in gastrointestinal system

- hemorrhagic diathesis

- chronic use of NSAIDs

- chronic use of opioids

- chronic use of anticoagulants

- female patient is known to be pregnant