Overview
Intravenous Paracetamol for Postoperative Pain
Status:
Completed
Completed
Trial end date:
2017-03-01
2017-03-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this study is to define if intravenous paracetamol may improve analgesia and outcome in pediatric surgical patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) postoperatively. Hypothesis: intravenous paracetamol in a dose 60 mg/kg/24 h IV, given in addition to IV ketoprofen (4,5 mg/kg/24h), improves analgesia and physical recovery in children and adolescents following surgery.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Lithuanian University of Health SciencesTreatments:
Acetaminophen
Anti-Inflammatory Agents, Non-Steroidal
Ketoprofen
Morphine
Pharmaceutical Solutions
Tramadol
Criteria
Inclusion Criteria:- Patients 1-18 years of age, undergoing general, plastic or orthopedic surgery with
expected median to severe pain postoperatively.
- physical status of the patient corresponding to American Society of Anesthesiologists
(ASA) class 1 or 2
- Signed written informed consent by parents/official caregivers.
Exclusion Criteria:
- Allergy to paracetamol, ketoprofen, tramadol, morphine or any NSAID
- oncologic disease
- central nervous system disease
- renal dysfunction
- hepatic dysfunction
- bronchial asthma
- ulcer(s) in gastrointestinal system
- hemorrhagic diathesis
- chronic use of NSAIDs
- chronic use of opioids
- chronic use of anticoagulants
- female patient is known to be pregnant