Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding

• Status: Completed
• Trial end date: 2009-04-01
• Target enrollment: 0
• Participant gender: All

Summary

A large dose of PPI is effective in preventing peptic ulcer rebleeding. The investigators hypothesize that 40 mg/q6h pantoloc is equivalent to 8mg/h pantoloc in preventing rebleeding.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lotung Poh-Ai Hospital
• Treatments: Pantoprazole; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• Patients were accepted for endoscopic therapy if a peptic ulcer with active bleeding, a non-bleeding visible vessel (NBVV) or an adherent blood clot at the ulcer base was observed within 24 hours of hospital admission.

Exclusion Criteria:

• If patients were pregnant

• Did not obtain initial hemostasis with endoscopic injection of epinephrine

• Did not give written informed consent

• Had bleeding tendency (platelet count < 50×109/L, serum prothrombin < 30% of normal, or were taking anticoagulants), uremia.