Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department

• Status: Completed
• Trial end date: 2017-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective: The purpose of this study is to determine if administering ketamine as an intravenous (IV) infusion over 15 minutes, as compared to an IV push, will decrease adverse drug reactions without attenuating its analgesic effects.

Study design: prospective, randomized, controlled, double-blind trial.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alameda Health System
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Pain NRS ≥5

• Anticipated stay in ED ≥1 hour

Exclusion Criteria:

• Pregnant or breast feeding

• Vital sign abnormalities (SBP <90, SBP > 180, HR < 50, HR > 150, RR <10, RR > 30, weight <45 kg, weight > 115 kg)

• Arrhythmias

• Altered mental status (active psychosis/delirium)

• Administration of opioid pain medication in previous 1 hour

• history of acute head or ocular trauma

• presence of known intracranial mass or vascular lesion